The Structure-Based Molecular Modeling laboratory @ Faculdade de Ciências from Universidade de Lisboa (FCUL) is dedicated to the use and development of computational approaches to study and identify regulatory structural determinants in proteins, membranes, and DNA, that could be used in the identification of new therapeutic agents against multiple diseases. We currently integrate different multidisciplinary projects within a network of international and national collaborations composed of both experimental and theoretical scientists with complementary scientific backgrounds.